- Take I-40 to Benson, NC.
- Take I-95 to Lumberton, NC.
- Take US 74 to Chadbourn, NC.
- Take US 410 to Tabor City, NC.
- Take US 701 to Conway, SC.
- Take US 501 to Myrtle Beach, SC.
Alternately, you could just take US 501 all the way down. It’s a little longer, but it’s direct and you get to pass by South of the Border.